Fig. 1: Forest plots showing the pattern of BMI effects of the four FRS3 missense variants identified in the study.
From: Missense variants in FRS3 affect body mass index in populations of diverse ancestries
The plots illustrate the associations between the four FRS3 missense variants identified in the study and BMI: a p.Glu115Lys (rs773053137-T), b p.Pro137Arg (rs146730626-C), c p.Pro172Leu (rs74687105-A), and d p.Arg316Gln (rs35744673-T). Data are presented as effect sizes in standard deviation (SD) units with 95% confidence intervals, combined (from the meta-analysis) and for individual studies. Effect sizes were determined using a linear mixed model implemented in BOLT-LMM, assuming an additive genetic model, and two-sided P values were calculated. The P values presented in the figure have not been adjusted for multiple comparisons. The vertical dashed line indicates effect size equal to zero and horizontal dashed lines separate effect estimates by ancestry. Effects are not shown for allele frequencies below 0.1%. Source data are provided as a Source Data file. AF allele frequency, EUR European, SAS South Asian, EAS East Asian, AFR African, UKB UK Biobank, CHB/DBDS Copenhagen Hospital Biobank/Danish Blood Donor Study, GIANT Genetic Investigation of Anthropometric Traits, NashBio Nashville Biosciences, MVP Million Veteran Program, AAAGC African Ancestry Anthropometry Genetics Consortium.
