Table 1 Top-15 predicted potential drugs for EGFR

From: DTIAM: a unified framework for predicting drug-target interactions, binding affinities and drug mechanisms

Rank

KEGG ID

Drug Name

Pred_Score

Validation

1

D01441

Imatinib mesylate

0.9962

BRENDA

2

D01977

Gefitinib

0.9961

DrugBank

3

D04023

Erlotinib hydrochloride

0.9954

KEGG,BRENDA

4

D04024

Lapatinib

0.9941

DrugBank

5

D03218

Axitinib

0.9937

BRENDA

6

D04025

Mubritinib

0.9918

KEGG

7

D03252

Bosutinib

0.9914

KEGG

8

D03350

Canertinib dihydrochloride

0.9851

BRENDA,DrugBank

9

D09883

Dacomitinib

0.9750

DrugBank

10

D10766

Osimertinib

0.9359

DrugBank

11

D08950

Neratinib

0.9308

DrugBank

12

D09724

Afatinib

0.9143

DrugBank

13

D07907

Erlotinib

0.9099

DrugBank

14

D10866

Brigatinib

0.8799

DrugBank

15

D12001

Mobocertinib

0.8106

DrugBank

  1. Note: The bolded drugs are the approved EGFR inhibitors collected from DrugBank, the others are the drugs in the Yamanishi_08’s dataset. The column Pred_Score indicates the predicted probability of the potential drug interacting with EGFR.
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