Fig. 3: Modification and deuteration reaction of drug derivatives. | Nature Communications

Fig. 3: Modification and deuteration reaction of drug derivatives.

From: Pd-catalyzed deuteration of aryl halides with deuterium oxide

Fig. 3

aReaction conditions: aryl (pseudo)halide (0.3 mmol, 1 equiv.), SPhos Pd G3 (5 mol%), ZnO (2.0 equiv.), B2eg2 (2.0 equiv.), D2O (4.0 equiv.), THF (0.2 M), N2 atmosphere, 70 °C, 12 h, isolated yields are reported, and deuterated ratios are reported in parentheses. bAdBrettPhos Pd G3 (5 mol%). cPd(tBu3P)2 (5 mol%), w/o ZnO, B2hex2 (2.0 equiv.).

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