Fig. 4: Manhattan plots and quantile-quantile (QQ) plots for genome-wide G×E analyses of two combinations of environmental factors and traits using SPAGxEmixCCT and SPAGxECCT. | Nature Communications

Fig. 4: Manhattan plots and quantile-quantile (QQ) plots for genome-wide G×E analyses of two combinations of environmental factors and traits using SPAGxEmixCCT and SPAGxECCT.

From: Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks

Fig. 4

Manhattan plots and QQ plots display the results of genome-wide analyses for two combinations of environmental factors and traits: a genetic sex and cardiac dysrhythmias (event rate: 8.83%) and b smoking status and chronic airway obstruction (event rate: 3.92%). SPAGxEmixCCT was applied to analyze 338,044 individuals of multiple ancestries for time-to-event traits (denoted as SPAGxEmixCCT (Surv-ALL)) and binary traits (denoted as SPAGxEmixCCT (Binary-ALL)). SPAGxECCT was applied to analyze 281,299 individuals of White British ancestry for time-to-event traits (denoted as SPAGxECCT (Surv-WB)) and binary traits (denoted as SPAGxECCT (Binary-WB)). The red line indicates the genome-wide significance level of \(\alpha=5\times {10}^{-8}\). Tests conducted in the analysis were two-sided.

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