Fig. 5: Regulation of SOGs by GABP.
From: Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases
a Distribution of SOGs ranked according to the number of tissues in which they show seasonal oscillation in male, female and both sexes. b GO enrichment analysis for the top 30 most common SOGs (one-sided Fisher’s exact test). c Distribution of potential transcription factors regulating SOGs ranked according to the number of tissues identified by transcriptional regulatory network analysis. d Effects of siRNA knockdown of GABPA and/or GABPB1 on GABPA and GABPB1 expression in macaque fibroblasts. (one-way ANOVA, Dunnett’s test, mean ± SEM, n = 4). e Effects of siRNA knockdown of GABPA and GABPB1 on the most common SOGs in macaque fibroblasts examined by qPCR (top) and RNA-seq (bottom) analyses. Numbers within the graph indicate the P value (unpaired two-tailed t-test, mean ± SEM, n = 4). f Comparison of 2,058 DEGs between GABPA and GABPB1 siRNA-treated and negative control siRNA-treated macaque fibroblasts (Benjamini-Hochberg correction adjusted P value (Padj) < 0.05 and fold change > 1.5). g Comparison of all 19,003 SOGs and 2058 GABP-regulated genes. h GO analysis of 1450 overlapping genes between SOGs and GABP-regulated genes (one-sided Fisher’s exact test).
