Fig. 1: Schematic diagram illustrating the synthesis of DAGQD@Cu@KGN-SO3−/DA-HA hydrogel and its application in RA treatment. | Nature Communications

Fig. 1: Schematic diagram illustrating the synthesis of DAGQD@Cu@KGN-SO3−/DA-HA hydrogel and its application in RA treatment.

From: Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy

Fig. 1

A Synthesis of DAGQD@Cu SAN and DAGQD@Cu@KGN SAN. B Synthesis of DAGQD@Cu@KGN-SO3−/DA-HA hydrogel. C DAGQD@Cu@KGN-SO3−/DA-HA hydrogel for RA therapy. (I) Hydrogel self-cures in situ within the joint cavity; (II, III) DAGQD@Cu@KGN-SO3−/DA-HA hydrogel displays lubrication and adhesion properties; (IV) Regulation of inflammatory microenvironment facilitated by SAN with remarkable ROS-scavenging capabilities; (V) KGN released from the hydrogel promotes the recruitment of BMSCs and induces their differentiation into chondrocytes, facilitating the repair of cartilage damaged by RA.

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