Fig. 6: Hydrogel prevents cartilage wear and tear in early RA. | Nature Communications

Fig. 6: Hydrogel prevents cartilage wear and tear in early RA.

From: Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy

Fig. 6

A Schematic illustration of the experimental procedure. B Micro-CT images of rat knee joints after 4 weeks of treatment. The yellow dotted line represents the location of the histological section of the rat. C, H, E and (D) Safranine-O stain images of rat knee joints after 4 weeks of treatment (n = 3 independent experiments). E–G Immunohistochemical staining of cartilage markers (Sox9、Col II and Acan). The black symbol represents the positive expression. Scale bar = 200 μm. H–J The quantitative analysis of cartilage markers (Sox9、Col II and Acan) (n = 3 samples). K–M Levels of IL-6, IL−1β, and IFN- γ in rat serum after 4 weeks of treatment (n = 3 samples). (Data are presented as the mean ± SD. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post-hoc test, with a value of *P < 0.05, **P < 0.01, and ***P < 0.005).

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