Fig. 7: Hydrogel promotes cartilage reconstruction in late RA. | Nature Communications

Fig. 7: Hydrogel promotes cartilage reconstruction in late RA.

From: Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy

Fig. 7

A Schematic illustration of the experimental procedure. B Macroscopic observation of repaired cartilages at 8 weeks (black arrow: defect cartilage site). C Micro-CT images of rabbit’s knee joints after 8 weeks of treatment. The blue dotted line represents the location of the histological section of the rabbit. D, H, E Safranine-O stain images of the rat knee joints after 8 weeks of treatment (n = 3 independent experiments). Scale bar = 2 mm. F Quantitative analysis of bone volume over total volume ratio (BV/TV) and (G) trabecular number (Tb.N) of CIA rats in different treated groups (n = 3 samples). H Histological synovitis scoring (HSS) and (I) modified Osteoarthritis Research Society International (OARSI) score of rabbit knee joints after 8 weeks of treatment (n = 5 samples). J Indentation test results and (K) corresponding reduced modulus of the newly formed tissues in different groups (n = 6 samples). (Data are presented as the mean ± SD. Ordinal data such as HSS score and OARSI score was analyzed by Kruskal-Wallis test and continuous data was analyzed by one-way ANOVA followed by Tukey’s post-hoc test, with a value of **P < 0.01, ***P < 0.005, and ****P < 0.001).

Back to article page