Fig. 1: Scheme of data generation and analysis overview. | Nature Communications

Fig. 1: Scheme of data generation and analysis overview.

From: Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis

Fig. 1

Ancestry-stratified GWAS meta-analyses were utilized to identify and fine-map genome-wide significant GWAS loci for atopic dermatitis risk. GWAS signal was integrated with functional maps and evaluated for cell-type context-specific enrichment and QTL colocalization; genes were prioritized per GWAS locus. The expression of a subset of prioritized genes was functionally characterized in keratinocytes for differentiation, cell-subtype specificity, knock-out (KO) and Quantitative Trait Loci (QTL) signal. This figure contains illustrations from BioRender. Oliva, M. (2025) [https://BioRender.com/r58o311].

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