Table 1 AD GWAS novel loci

Lead Variant	Chr:Pos	Nearest gene	OpenTargets V2G	P-value	Effect size	SE	MAF	GWAS meta-analysis	Replication study (P < =5e−06)
rs11247907	1:26309552	CD52	UBXN11	4.97E−08	0.05	0.009	0.17	MULTI	Hirota¹⁵, Budu-Aggrey¹⁴
rs10183338	2:110853239	ACOXL	BCL2L11	2.15E−10	−0.05	0.008	0.30	MULTI + EUR
rs10195173	2:190753596	NAB1	GLS	6.49E−09	−0.04	0.007	0.40	MULTI + EUR
rs140759564	2:201461659	STRADB	PPIL3	2.75E−08	0.21	0.038	0.02	MULTI + EUR
rs7731626	5:56148856	IL6ST	ANKRD55	3.59E−09	−0.05	0.008	0.27	MULTI + EUR
rs9313491	5:157194894	ITK	ITK	2.27E−08	−0.04	0.007	0.37	MULTI	Budu-Aggrey¹⁴
rs9494672	6:137152938	IL22RA2	IL22RA2	2.57E−10	0.13	0.021	0.03	MULTI	Budu-Aggrey¹⁴
rs7758477	6:154790790	TIAM2	SCAF8	2.10E−08	0.05	0.008	0.43	EUR
rs7787688	7:22768265	IL6	STEAP1B	2.26E−08	0.04	0.008	0.51	MULTI
rs79376089	8:60929420	CHD7	CHD7	6.92E−11	0.12	0.018	0.05	MULTI + EUR	Budu-Aggrey¹⁴
rs11817236	10:60742008	CDK1	ANK3	3.44E−08	−0.04	0.008	0.48	EUR
rs541390276	11:67602285	NDUFV1	GSTP1	8.81E−09	0.18	0.032	0.02	MULTI + EUR
rs718389	12:874384	RAD52	WNK1	2.67E−09	0.05	0.009	0.42	EUR	Budu-Aggrey¹⁴
rs175714	14:75515513	BATF	BATF	4.48E−09	0.04	0.007	0.49	MULTI	Baurecht¹⁶
rs68154225	17:78372835	PGS1	SOCS3	3.62E−08	−0.09	0.016	0.05	MULTI	Budu-Aggrey¹⁴
rs11152086	18:58572798	ALPK2	ALPK2	4.02E−09	0.06	0.009	0.23	EUR

Summary statistics and genomic context of the 16 AD GWAS loci not previously reported in eczema and AD GWAS studies (Methods). Genomic coordinates based on human genome reference hg38. Nearest gene and OpenTargets V2G annotation approaches are described in Methods. P-value, effect size and standard error (SE) estimates are derived from a two-sided test for effect size in a fixed-effect inverse variance weighted approach (Methods). Minor Allele Frequency (MAF) corresponds to effect allele frequency. Summary statistics correspond to the multi-ancestry (MULTI) AD GWAS meta-analysis, or to the European (EUR) GWAS meta-analysis for cases with detectable signal only in that cohort—rs7758477, rs11817236, rs718389 and rs11152086. The GWAS p-values considered for replication correspond to ones reported to the EBI GWAS Catalog by corresponding authors.

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