Fig. 4: Results, interpretation and evaluation of baseline and full models on the EOPE patient subset.
From: Predicting interval from diagnosis to delivery in preeclampsia using electronic health records
A The bar plots of C-indices from the original Cox-nnet EOPE baseline model (red) and feature-reduced clinically informative model (blue) on the UM cross-validation (5 technical replications, error bars represent median ±SD), UM test set and UF test set. B, C The survival curves and 95% CI(mean ±1.96SEM) of high-risk (top 25%), intermediate-risk (middle 50%) and low-risk groups (bottom 25%), categorized by predicted PI from the reduced EOPE baseline model in (A) on (B) UM hold-out test set, (E) UF test data. C, F ROC curves of prediction delivery time within 2 days, 7 days and 14 days using results from reduced EOPE baseline model (A) on (C) hold-out UM test data and (F) UF test data. D The ln-transformed permutation importance score of features in the EOPE full model. Color represents p-values of two-sided univariate Cox-PH test. G The bar plots of C-indices from the original Cox-nnet EOPE full model (red) and its feature-reduced clinically informative model (blue) on the cross-validation and UM test set(5 technical replications, data are represented as mean ±1.96SEM) and UF test set. H, K The survival curves and 95% CI(mean ±1.96SEM) of high-risk (top 25%), intermediate-risk (middle 50%) and low-risk groups (bottom 25%), categorized by predicted PI from the reduced EOPE full model in (G) on (H) UM hold-out test data, (K) UF test data. I, L ROC curves of prediction delivery time within 2 days, 7 days and 14 days using results from reduced EOPE full model (G) on (I) UM hold-out test data and (L) UF test data. J The ln-transformed permutation importance scores of features in the EOPE full model. Color represents p-values of two-sided univariate Cox-PH test. M–O Analysis of creatinine values among the EOPE patients in the discovery cohort. M The dichotomized survival curves and 95% CI(mean ±1.96SEM) by the median value of creatinine. N, O Distributions of creatinine values by delivery gestational week (N) and diagnosis-to-delivery time (O). P–R Analysis of platelet counts among the EOPE patients in the discovery cohort. P The dichotomized survival curves and 95% CI(mean ±1.96SEM) by the median value of platelet counts. Q, R Distributions of creatinine values by delivery gestational week (Q) and diagnosis-to-delivery time (R).
