Table 1 IC50 values of Compounds A–Ea against recombinant human VAP-1 and native human MPO

From: Targeting vascular adhesion protein-1 and myeloperoxidase with a dual inhibitor SNT-8370 in preclinical models of inflammatory disease

Compound

VAP-1 potency (IC50)

MPO potency (IC50)

PXS-4728

0.005 μM41

>30 μM

AZD5904

>30 μM

0.055 μM

Verdiperstat

>30 μM

0.038 μM

PF06282999

>30 μM

0.113 μM

A

13.1 μM

0.126 μM

B

5.6 μM

0.232 μM

C

0.185 μM

0.148 μM

D

0.003 μM

>30 μM

E (SNT-8370)

0.010 μM

0.017 μM

  1. Values are the average of at least 3 experiments. Enzyme activity of VAP-1 or MPO was measured as the rates of H2O2 production or consumption, respectively using the Amplex Red assay.
  2. aSee Fig. 2 for structures of all compounds.
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