Fig. 9: A graph model for the role of adipose KLF10 in exercise-induced anti-obesity and metabolic improvement effects. | Nature Communications

Fig. 9: A graph model for the role of adipose KLF10 in exercise-induced anti-obesity and metabolic improvement effects.

From: Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis

Fig. 9

KLF10 in mature adipocytes is upregulated by SIRT1/FOXO1 axis in response to exercise and then interacts with FOXO1 to recruit histone lysine demethylase 4A (KDM4A) and form a ternary complex, thereby strengthening the transcription of key lipolytic genes (Pnpla2 and Lipe) to promote lipolysis. Free fatty acids (FFAs), the products of lipolysis, could act as a ligand of PPARα to activate it. And then PPARα increases the expression of fatty acid oxidation (FAO) genes (such as Cpt1b) and browning genes (such as Ucp1) to fuel adipose catabolism. The above FOXO1-KLF10 reinforcing loop contributes to exercise-mediated anti-obesity and metabolic improvement effects in mice. The graph model was created in BioRender. Zhu, J. (2023) BioRender.com/e08n146.

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