Table 2 Summary of top variants in the MLXIPL gene cluster exhibiting genome-wide significance for the TyG index, a marker of insulin resistance, identified within the Taiwan Biobank cohort

GENE	CHR	Interval (b38)	Top SNP	Pos (b38)	Top P	Novel	TWAS	GWAS catalog
POM121	7	72879357..72951459	rs117135057	72,938,316	1.8E-08	yes	NA	TG, BMI
NSUN5	7	73302516..73308826	rs3750074	73,308,628	1.1E-17	yes	NA	NA
FKBP6^a	7	73328161..73358625	rs186391487	73,384,030	9.2E-18	yes	1, 2	TG
FZD9	7	73433778..73436120	rs1178947	73,435,848	5.8E-69	yes	9	TG, HDL-C
BAZ1B	7	73440406..73522293	rs111837003	73,493,129	1.2E-71	yes	1, 4, 6, 10, 11	TG, HDL-C
BCL7B	7	73536356..73557690	rs13244614	73,559,524	9.0E-84	yes	1, 2, 8, 9	HDL-C
TBL2	7	73567537..73578579	rs13246490	73,578,020	2.6E-84	yes	NA	TG, HDL-C, BMI
MLXIPL	7	73593202..73647907	rs3812316	73,606,007	8.5E-105	no	1, 2, 3, 9, 10, 11	TG, HDL-C, BMI, TG:HDL-C
VPS37D^a	7	73665347..73672110	rs371515311	73,660,465	6.1E-16	yes	1	TG, HDL-C
DNAJC30	7	73680918..73683453	rs3828973	73,682,169	1.3E-09	yes	NA	TG
ABHD11^a	7	73736094..73738802	rs10226706	73,751,424	3.6E-08	yes	5	TG
CLDN3	7	73768997..73770270	rs6460054	73,770,204	3.0E-08	yes	NA	TG
TMEM270^a	7	73860848..73865890	rs73144858	73,922,565	2.7E-13	yes	7	NA
ELN^a	7	74028173..74069907	rs188072556	73,999,294	1.3E-15	yes	10	NA
RFC2	7	74231502..74254399	rs148741166	74,252,973	1.2E-10	yes	NA	TG
CLIP2	7	74289407..74405935	rs151126504	74,392,493	1.0E-13	yes	NA	NA
GTF2IRD1^a	7	74453906..74602605	rs145049525	74,440,602	9.0E-09	no	NA	TG, BMI, TG:HDL-C
TAD	CHR	Interval (b38)	--	--	--	--	--	--
pancreas	7	73160000..74760000	--	--	--	--	--	--
hippocampus	7	73280000..74760000	--	--	--	--	--	--
liver	7	73280000..74760000	--	--	--	--	--	--

Tissues in TWAS: 1 = Adipose Subcutaneous; 2 = Adipose Visceral Omentum; 3 = Adrenal Gland; 4 = Brain Cortex; 5 = Brain Hippocampus; 6 = Brain Hypothalamus; 7 = Liver; 8 = Muscle Skeletal; 9 = Pancreas; 10 = Pituitary; 11 = Thyroid. Previous GWASs reported in the NHGRI-EBI GWAS Catalog have identified various phenotypes that reach genome-wide significance (P < 5 × 10⁻⁸). Coordinates for TADs were retrieved from the following source (http://3dgenome.fsm.northwestern.edu/publications.html).
AD Alzheimer’s disease, b38 Genome Research Consortium human build 38, BMI body mass index; CHR chromosome, FG fasting glucose, HDL-C high-density lipoprotein cholesterol, IR insulin resistance, NA not available, Pos position, T2D type 2 diabetes, TAD topologically associating domains, TG triglycerides, TG:HDLC the triglyceride to high-density lipoprotein cholesterol ratio, TWAS transcriptome-wide association analysis.
^aNearby gene. -- not applicable. This GWAS analysis utilized BOLT-LMM’s mixed linear models with a two-sided chi-square test. The conventional genome-wide significance threshold of P < 5 × 10⁻⁸ was applied.

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