Fig. 1: UpSet plots of gene/protein-based findings across omics. | Nature Communications

Fig. 1: UpSet plots of gene/protein-based findings across omics.

From: Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Fig. 1

UpSet plot (an extension of Venn diagrams to visualize overlap of more than three datasets) for type 2 diabetes (A) HDL cholesterol (B), LDL cholesterol (C) total cholesterol (D) triglycerides (E) and showing all nominally significant (p < 0.05) annotation results across gene/protein-based analyses for novel genes identified in S-PrediXcan discovery genetically regulated expression association analyses: Mendelian randomization of S-PrediXcan findings, transcriptomic association analyses, and proteomic association analyses. Intersections empty for all traits are excluded (GReX, MR, RNASeq, and Proteomics; and GReX, RNASeq, and Proteomics). GReX represents genetically regulated expression analysis (S-PrediXcan) results, MR represents Mendelian randomization results, RNASeq represents transcriptomic differential expression results, and Proteomics represents proteomic differential abundance results. Blue represents novel loci, purple represents novel genes/proteins in known loci, and pink represents known genes/proteins in known loci.

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