Fig. 5: The multimorbidity mechanisms and age-related risk trends across multiple diseases.
From: UKB-MDRMF: a multi-disease risk and multimorbidity framework based on UK biobank data
a Two-dimensional projection of the disease prediction model’s multimorbidity mechanisms using t-SNE, where each point represents a predicted Phecode, and each color represents a major disease type. Closer points indicate similar disease patterns. The six circles in the figure delineate specific multimorbidity patterns. b Multimorbidity patterns of selected clusters' internal Phecodes. The size of each data point indicates the number of affected individuals, with larger points representing higher frequencies of occurrence. The thickness of the lines represents the frequency of comorbidity, with thicker lines indicating higher frequencies. c Risk profiles of nine major disease types estimated by the DeepSurv model across different age groups. The size of the circles indicates the cumulative number of affected individuals, with larger circles representing higher numbers. The shading represents the magnitude of risk, with darker shades indicating higher risk levels. Icons provided by Icons8 (https://icons8.com).
