Fig. 1: Postnatal fluoxetine (PND2-11) increases freezing to a predator.
From: Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans
A Timeline of the adult mouse behavioral study. Created in BioRender. Zanni, G. (2025) https://BioRender.com/m34p441. B Manual freezing score during habituation early and late phases. C Manual freezing score during context re-exposure and during predator odor. D Latency to freeze expressed as percent change of habituation freezing latency. E Labeling of different animal body parts: nose (purple), tail base (orange), right ear (electric blue), left ear (cyan), right hip (blue), left hip (light blue), mid back (yellow). Top picture shows animals exploring and the bottom picture shows an animal freezing. F Deeplab Cut freezing score during context re-exposure and during predator odor. G Deeplab Cut speed scoring during context re-exposure and during predator odor. Data are presented as mean values +/- SEM. Statistical tests used: ANOVA and Fisher’s LSD posthoc. PNSAL N = 13, PNFLX N = 11. *p < 0.05; **p < 0.01; ***p < 0.001. Source data are provided as a Source Data file.
