Fig. 2: Preconfigured ensembles are aligned across both pre- and postlearning sleep in engram cells. | Nature Communications

Fig. 2: Preconfigured ensembles are aligned across both pre- and postlearning sleep in engram cells.

From: Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep

Fig. 2

A Schematic diagram of the tracking of all learning ensembles with ensembles detected in other sessions (pre-, post-learning sleep, and retrieval). Ensemble pairs have green-filled circles or blue hollow circles indicating activation or absence of that ensemble, respectively. Ensembles were considered active if the ensemble pair, from a different session, had normalized cosine similarity >0.6. B, C Pie charts showing percentage of ensembles relative to the learning session (A) using the NREM sleep only (B) or the REM sleep only (C) in pre- and post-learning sleep. B n = 6 mice. *p < 0.05, ***p < 0.001, ****p < 0.0001. Statistical comparisons were made using Repeated-measures two-way ANOVA with Sidak’s multiple comparisons test (B, C). Data represent the mean ± s.e.m. The Experiment was independently repeated six times. Source data are provided as a Source Data file. Detailed statistics are shown in Supplementary Data 1.

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