Fig. 6: Abolishing sleep plasticity in the network model hinders emergence of engram-to-be cells. | Nature Communications

Fig. 6: Abolishing sleep plasticity in the network model hinders emergence of engram-to-be cells.

From: Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep

Fig. 6

A Percent of neurons of engram, engram-to-be, and other nonengram cells in the normal plasticity and sleep plasticity OFF models. n = 5 simulations. B Comparing the pairwise correlations within groups (engram, engram-to-be, and other nonengram) computed through the normal model parameters and sleep plasticity OFF model. n = 5 simulations. C Normalized coincidence ratio during postlearning sleep in the sleep plasticity OFF model. n = 5 simulations. D Differences in the coincidence ratios between common engram and engram-to-be, and specific engram and engram-to-be, in the normal parameters model and sleep plasticity OFF model. n = 5 simulations. ***p < 0.001, ****p < 0.0001, n.s., nonsignificant. Data represent the mean ± s.e.m. Statistical comparisons were made using two-way ANOVA with Sidak’s multiple comparisons test (A), Repeated-measures two-way ANOVA with Sidak’s multiple comparisons test (B), one-way ANOVA with Tukey’s multiple comparison’s test (C) and a paired t test two-tailed (D). The Experiment was independently repeated five times. Source data are provided as a Source Data file. Detailed statistics are shown in Supplementary Data 1.

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