Fig. 3: Inter-subunit interactions and disease-relevant residues in the NTD-ring of the SPATA5 complex.
From: Cryo-EM structure of the AAA+ SPATA5 complex and its role in human cytoplasmic pre-60S maturation
a Top view of the atomic model of the SPATA5 complex NTD-ring. The components are color-coded, as in Fig. 2. b Zoomed-in view of the interfaces among CINP, C1orf109, and SPATA51. c–e Close-up view of the interactions between C1orf109 with CINP (c), between SPATA51 and C1orf109 (d), and between SPATA51 and CINP (e). Interacting residues are shown and labeled, with disease-relevant residues labeled in bold (e.g., R84 and G185 of SPATA5). f Zoomed-in view of the interface between SPATA52 and CINP. g Close-up view of the interactions between SPATA52 and CINP. h Zoomed-in view of the interface between C1orf109 and SPATA52. i Close-up view of the interactions between SPATA52 and C1orf109. j Zoomed-in view of the interfaces among SPATA52, C1orf109, and SPATA5L1. k–m Close-up views of the interactions between SPATA5L1 and SPATA52 (k), and between SPATA5L1 and C1orf109 (l, m).
