Fig. 3: Summary of Vex-seq analysis.
From: Functional impact of splicing variants in the elaboration of complex traits in cattle
a Average PSI for reference and alternative alleles of the 27 CSSV that are part of the Var.GWAS and Var.P datasets. Of note, one CSSV (rs448758869) resulting in a GT > GC transition still allowed the test exon to be included efficiently (arrow). Box plots are defined as follow; cross, mean; centre line, median; box limits, upper and lower quartiles; top and bottom whisker lines, maximum and minimum values; points, outliers. b Average PSI for reference and alternative alleles of variants from whole Var.GWAS and Var.P datasets. Box plots are defined as in (a). c Average │∆PSI│ variant by dataset. Box plots are defined as in (a). d Proportion of tested variants confirmed to be SDV determined for each dataset. Variants with ∆PSI above 5% or below 5% were considered to be SDV. FDR false discovery rate used to identify SDV. H HEK293T, M MAC-T. e Overlap of SDV from merged Var.GWAS and Var.P datasets between HEK293T and MAC-T cell lines. Scatter plot of f PSI and g ∆PSI values from merged Var.GWAS and Var.P datasets in HEK293T versus MAC-T cells. r Pearson correlation coefficient. Source data are provided as a Source Data file.
