Fig. 7: P. aeruginosa isolate FRD1 harbors signature of evolution in the tolerant lung.
From: A host-pathogen metabolic synchrony that facilitates disease tolerance
a Number of non-synonymous mutations (# NSM) and gene expression level (logFC) for loci involved in EPS synthesis in FRD; control: WT PAO1. Mice were exposed to either PBS, WT PAO1, FRD1 or ΔalgD FRD1 (n = 2, total of 11-12 mice per group). The following were analyzed: b pathogen burden; c BAL cytokines; d BAL albumin; e body temperature; f Animal survival. Data are shown as average +/− SEM. B-E: One-Way ANOVA (Tukey multiple comparison test); f Kaplan-Meier. All statistical tests are two-sided. Source data are provided as a Source Data file.
