Fig. 2: Substrate scope for enantioselective synthesis of ICCs regarding electrophilic azo reagents and substitutions at the lower rim. | Nature Communications

Fig. 2: Substrate scope for enantioselective synthesis of ICCs regarding electrophilic azo reagents and substitutions at the lower rim.

From: Catalytic enantioselective synthesis of inherently chiral calix[4]arenes via organocatalyzed aromatic amination enabled desymmetrization

Fig. 2

Reactions were performed with prochiral calix[4]arenes 1 (0.05 mmol), azo reagents 2 (0.06 mmol) and CPA catalyst (0.0005 mmol, 1 mol%) in DCM (1.5 mL) at 20 °C for 24 h. Isolated yields were reported. The dr and ee values were determined by HPLC analysis using a chiral stationary phase. The products not reporting dr values indicated that only one diastereomer was observed by HPCL analysis (>20:1 dr). aThese reactions were performed at −40 °C.

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