Fig. 3: Structural comparisons of the pre-mature and mature hexons.

a Top Left: Ribbon diagrams showing domain organization of the mature hexon. The N terminal fragment (residues 1–55), N-jelly roll, C-jelly roll, loops DE1, DE2, FG1, FG2 and the connecting β sheet are colored firebrick, spring green, orange, yellow, red, deep sky blue, lime and cornflower blue, respectively. Bottom Left: Structural comparisons of the pre-mature and mature hexons. Middle: Top (Left) and front views (Right) of the superimposition of pre-mature and mature hexons. The black triangle depicts the position of the 3-fold symmetry axis. Right: Relative positions of the double jelly-roll domains in the pre-mature and mature hexons. The centroids were calculated with the top insertion and bottom jelly-roll domains, respectively. Centroids of the pre-mature and mature hexons are colored red and blue, respectively. b Structural comparisons of the jelly-roll domains in mature and pre-mature hexons. The N terminal fragment (residues 1–55), N-jelly roll, C-jelly roll, loop DE2 and the connecting β sheet of one hexon protomer are colored firebrick, spring green, orange, red and cornflower blue, respectively. The positions of the disordered regions (1–47, 724–730, 740–753, 766–781, 868–891, and 915–944) in the pre-mature hexon are represented with dash lines. The N- and C-termini of the colored premature hexon protomer are highlighted with red balls. c.Structural superimposition of the top insertion loops and the bottom double jelly-roll domains of the pre-mature and mature hexons. The top insertion loops and the bottom double jelly-roll domains of the mature hexon are colored the same as in the left top panel of (a). The pre-mature hexon are colored gray.