Fig. 7: Transition in metagene expression during dupilumab treatment based on the longitudinal study. | Nature Communications

Fig. 7: Transition in metagene expression during dupilumab treatment based on the longitudinal study.

From: An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis

Fig. 7

A Average expression of skin metagenes during dupilumab treatment in 24 patients. The p values indicate the significance of the differences in metagene expression compared with the pretreatment level (month 0) as determined by a linear mixed-effects regression analysis. n = 24 (AD), 26 (normal). *p < 0.01. P values were corrected using the Bonferroni method for multiple comparisons. Source data are provided as a Source Data file. B Averaged transition in skin metagene expression among different responder groups. In (A, B), the mean and SEM (standard error of the mean) are presented as red and blue points and bars, respectively, for lesional and non-lesional AD skin samples. Green highlighted shadows represent the 95% confidence interval (CI) for the mean expression in healthy individuals. n = 5 (early responders), 11 (intermediate responders), 8 (poor responders).

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