Fig. 1: Rationale for the design of disaccharide lipid A mimetics (DLAMs).
From: Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes
a Schematic representations of LPS, structure of Re/Ra-LPS (stick model from PDB: 3FXI), and chemical structure of E. coli LPS. b Crystal structure of the hTLR4/MD-2/Ra-LPS complex (PDB code: 3FXI). TLR4 and MD-2 are shown as cartoons, with Ra-LPS displayed as spheres. c Design of Disaccharide Lipid A Mimetics (DLAMs) based on α,α-1,1′-disaccharide scaffold.
