Fig. 4: Atomic structures of DLAM3-bound hTLR4/MD-2 and mTLR4/MD-2, revealing species-specific binding orientations.
From: Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes
a and b The detailed interactions of DLAM3 with hTLR4/MD-2 (a) and mTLR4/MD-2 (b). The direct interactions with DLAM3 are indicated by dashed lines as in Fig. 3. The colors of DLAMs and TLR4/MD-2 are consistent with Fig. 2c. c Superimposition of DLAM3 bound to h- and mTLR4/MD-2 complexes demonstrating species-specific binding poses. Superimposition of DLAM3 and E.coli lipid A part of LPS bound to hTLR4/MD-2 (d) and mTLR4/MD-2 (e). The colors of DLAMs and TLR4/MD-2 are consistent with Fig. 2c.
