Fig. 5: Correlations between differentially abundant species and metabolites grouped by disease type.
From: Association of distinct microbial and metabolic signatures with microscopic colitis
a Metabolites and species are classified and clustered as MC-enriched (brown) or control-enriched (blue, including controls without diarrhea and chronic diarrhea). Metabolites are further grouped by metabolite class. The abundance of metabolites and microbes covariate concordantly with a clear pattern that MC-enriched species and metabolites (or control-enriched species and metabolites) are positively correlated, while MC-enriched species and control-enriched metabolites (or control-enriched species and MC-enriched metabolites) are negatively correlated. Source data are provided as a Source Data file. *** FDR q < 0.05; ** 0.05 ≤ FDR q < 0.1; * 0.1 ≤ FDR p < 0.25. b Correlations between sphingolipids (MC-enriched metabolite) and species. Source data are provided as a Source Data file. c, d Examples of individual correlations between MC-enriched sphingolipids and V. parvula (MC-enriched) or Methylobacterium SGB15164 (control-enriched). Concordantly, positive correlations are observed between MC-enriched species and MC-enriched sphingolipids, while negative correlations are found between control-enriched species and MC-enriched sphingolipids. Source data are provided as a Source Data file.
