Fig. 5: The activation of CaV1.1 VSD-III is the earliest molecular transition responsible for the electro-mechanical opening of RyR1. | Nature Communications

Fig. 5: The activation of CaV1.1 VSD-III is the earliest molecular transition responsible for the electro-mechanical opening of RyR1.

From: The molecular transition that confers voltage dependence to muscle contraction

Fig. 5

a Summary of the VSD properties that fit those of skeletal muscle Ca2+ release. b During a skeletal muscle AP, the displacement of the charged VSD-III controls RyR1 activation and muscle contraction. For simplicity, the interaction of one CaV1.1 and one RyR1 monomer is shown. Created in BioRender. Angelini, M. (2025) https://BioRender.com/z78y343.

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