Fig. 4: Sequence and structure conservation of class 2 xrRNAs from flavivirus.
From: Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure
A Consensus secondary structure model of class 2 xrRNAs calculated by R-Scape76,79. B Diagram denoting the location of three perfectly conserved A bases that were mutated to test their functional significance. C. Structure of the POWV xrRNA with the three conserved A bases indicated in B and C. D. In vitro RNA resistance assay demonstrating the functional importance of the three perfectly conserved (A) nucleotides in class 2 xrRNAs. The gel is representative of experiments performed in triplicate. Source data are provided as a Source Data file.
