Fig. 7: Schematic illustration of study design. | Nature Communications

Fig. 7: Schematic illustration of study design.

From: Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria

Fig. 7

A total of 180 patients transplanted from 2015–2019 were included (100 patients as derivation cohort, 80 patients as validation cohort). Samples from the derivation cohort were subjected to RNA-seq, ATAC-seq, and proteomic analyses. In vivo, in vitro experiments, and formalin-fixed paraffin-embedded HCC samples were used to validate the mechanisms. HCC hepatocellular carcinoma, ATAC-seq assay for transposase-accessible chromatin sequencing, IHC immunohistochemistry, mIF multiplex immunofluorescence. The figure was created with BioRender.com.

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