Fig. 4: Scope of reaction with epoxides, cyclic carbonates and α-hydroxycarboxylate. | Nature Communications

Fig. 4: Scope of reaction with epoxides, cyclic carbonates and α-hydroxycarboxylate.

From: Trifluoroethanol-assisted asymmetric propargylic hydrazination to α-tertiary ethynylhydrazines enabled by sterically confined pyridinebisoxazolines

Fig. 4

Reaction conditions: 1 (0.2 mmol), hydrazide 2 (0.24 mmol), CuCl2·2H2O (10 mol%), L9 (12 mol%), DABCO (0.2 mmol), CF3CH2OH (2.0 mL), –20 °C, 2 days. aL13 was used; for details see Section 6 of the SI. Isolated yield. The e.e. values were determined by chiral HPLC analysis. The absolute configuration of (S)−8i was determined by X-ray analysis. The absolute configuration of (S)−8j was determined by converting the ester group into a hydroxymethyl group and comparing the optical rotation value with that of the (S)−8a.

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