Fig. 1: Validation of ENPP1 as an innate immune checkpoint in solid tumors and indication prioritization for ENPP1 targeting strategies. | Nature Communications

Fig. 1: Validation of ENPP1 as an innate immune checkpoint in solid tumors and indication prioritization for ENPP1 targeting strategies.

From: Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors

Fig. 1

A Indication prioritization tools embedded in PandaOmics to rank indications for ENPP1. B The correlation analysis of type-I IFN related immune parameters across cancer types: Correlation between ENPP1 expression in tumor cells and ISG score in conventional dendritic cells (cDC) in gastric cancer (OMIX001073, n = 10) and colorectal cancer (CRC, GSE132465, n = 23), as well as correlation between ENPP1 expression in tumor cells and CXCL10 expression in dendritic cells (DC) and cDC percentage in triple-negative breast cancer (TNBC, GSE176078, n = 10). Each dot represents a single patient sample. The x-axis indicates the ENPP1 expression in tumor cells and the y-axis displays the corresponding immune parameters: ISG score, CXCL10 expression or cDC percentage. The P value and correlation were performed using Pearson’s correlation coefficient, with the resulting trend line depicted in blue. The gray shaded area surrounding the trend line represents the 95% confidence intervals. Source data are provided as a Source Data file. C Spatial distribution of ENPP1, ISG score and predicted proportion of CD8 T and pro-inflammatory macrophage cells per spot in histology slide SN84_A120838_Rep2 from CRC patient (Zenodo record: 7760264). The color represents the value of ENPP1 expression, ISG score and predicted proportion of DC and NK cells per spot. Source data are provided as a Source Data file. D Spatial distribution of ENPP1, ISG score and predicted proportion of CD4 T and DC cells per spots in slide GSM6433591_094A from a TNBC patient (GEO: GSE210616). The color represents the value of ENPP1 expression, ISG score and predicted proportion of DC and NK cells per spot. Source data are provided as a Source Data file. E Spatial distribution of ENPP1, ISG score and predicted proportion of DC and NK cells per spot in slide 21_00734_LI_SING from a GC patient (GEO: GSE251950). The color represents the value of ENPP1 expression, ISG score and predicted proportion of DC and NK cells per spot. Source data are provided as a Source Data file.

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