Fig. 8: Diagram illustrating the mechanism through which ISM5939 potentiates antitumor immune responses. | Nature Communications

Fig. 8: Diagram illustrating the mechanism through which ISM5939 potentiates antitumor immune responses.

From: Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors

Fig. 8

ISM5939 facilitates the accumulation of extracellular cGAMP by blocking ENPP1-dependent degradation, thereby triggering the cGAS-STING signaling pathway in antigen-presenting cells (APCs). This activation effectively enhances the activity of CD8 + T cells. Additionally, ISM5939 diminishes adenosine production by inhibiting ENPP1-mediated ATP hydrolysis, potentially mitigating the suppression of tumor-infiltrating T cells.

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