Fig. 8: Intra-articular injection of lentiviruses expressing FOXO3 attenuates OA lesions and caused upregulation of ferroptosis in the subchondral bones of obese mice. | Nature Communications

Fig. 8: Intra-articular injection of lentiviruses expressing FOXO3 attenuates OA lesions and caused upregulation of ferroptosis in the subchondral bones of obese mice.

From: Regulating obesity-induced osteoarthritis by targeting p53-FOXO3, osteoclast ferroptosis, and mesenchymal stem cell adipogenesis

Fig. 8

a–f IHC staining of Gpx4 (a), Slc7a11 (c), and Fsp1 (e) was performed on the subchondral bone of joints from mice fed with an HFD after intra-articular injection of lentiviruses expressing FOXO3. The percentage of positive cells in the subchondral bone was quantified. n = 6 mice per group. Scale bar, 100 µm. The sham group received an injection of lentiviral blank vector, while the FOXO3 group received an injection of lentivirus expressing FOXO3. Data are represented as mean ± s.d. One-way ANOVA was performed. All exact p-values have been indicated in the figures. Source data are provided as a Source Data file.

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