Fig. 3: Flexible N-terminal domain region in ADAR1 monomer.
From: High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes
a The domain structures of ADAR1-p110. b Selected frames show the structural insight of the ADAR1 monomer over time. The monomer shows the dsRBDs with the Zβ domain (N-terminal domains) and a deaminase domain in one-tailed and globular structures, respectively. The tail protruding from the globular structure hides behind it. c Cross-sectional analysis of the monomer clearly shows fluctuations in the peak-to-peak distance between dsRBDs with the Zβ and the deaminase domains. d The height of the PDB structure of the deaminase domain using PYMOL online software and the distribution of the height peaks in the HS-AFM images of the deaminase domain were observed. Imaging parameters: scanning area = 100 × 100 nm2 (150 × 100 pixels); frame rate = 3.3 frames/s. The displayed area is 43 × 40 nm2. Source data of the graphs are provided as a Source Data file.
