Fig. 7: Synthesis applications inspired by biologically active heteroaryl-containing molecules, including macrocycles and atropopeptides. | Nature Communications

Fig. 7: Synthesis applications inspired by biologically active heteroaryl-containing molecules, including macrocycles and atropopeptides.

From: Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates

Fig. 7

a Synthesis of modifiable atropisomeric macrocycles by ring-closing metathesis. b Synthesis of linear and macrocyclic atropopeptides, inspired by naturally-occurring and antibacterial compounds such as cihunamide B (Fig. 1) and several others. c Inducing conformational changes (and chirality) by means of atropisomerism to heterobiaryl pharmaceuticals. This strategy is applicable to countless molecules in early drug discovery screenings.

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