Fig. 1: Background and our reaction.
From: Copper-catalyzed enantioselective three-component radical 1,4-perfluoroalkylamination of 1,3-dienes
a Examples of biological and pharmaceutical active molecules with perfluoroalkylated chiral allylic amine substructure. b Transition metal-catalyzed asymmetric aminative difunctionalization of 1,3-dienes. c Transition metal-catalyzed asymmetric 1,2-three-component aminativedifunctionalization of 1,3-dienes with aniline derivatives. d This work: enantioselective three-component radical 1,4-perfluoroalkylamination of 1,3-dienes with aniline derivatives.
