Fig. 2: Scope of the substrates. | Nature Communications

Fig. 2: Scope of the substrates.

From: Copper-catalyzed enantioselective three-component radical 1,4-perfluoroalkylamination of 1,3-dienes

Fig. 2

a Scope of 1,3-dienes. b Scope of anilines. Reaction conditions: 1 (0.25 mmol), 2 (0.1 mmol), 3a (0.2 mmol), Cu(CH3CN)4PF6 (10 mol%), (R, R)-L1 (12 mol%) in 2 mL mixed solvent of CH3CN and EA (1:4) at −10 °C for 72 h under nitrogen. Yields were isolated ones. Er values were determined by HPLC analysis. Dr values were determined by 1H NMR analysis. aReaction for 5 days.

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