Fig. 2: Schematic diagram of a dual-solvent assisted ion-exchange approach.

Intense agitation of an aqueous CALB-TBA solution and a DCM Pd@C-Cage-TFSI solution leads to a rapid combination of hydrophobic TBA+ and TFSI− species in the oil phase. Simultaneously, the cationic Pd@C-Cage+ component dissociates from the oil phase, merging with CALB− in the aqueous phase to maintain the charge balance. This results in the formation of the integrated chemoenzymatic catalyst (Pd@C-Cage-CALB) through electrostatic complexation.