Fig. 3: Circular Manhattan plot of significant loci associated with asthma in East Asian populations.
From: Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians
Circular plot illustrating pleiotropic loci shared between asthma and eosinophil traits across the genome. The outermost ring represents human chromosomes (chr1 to chr22), while the subsequent inner rings display significant associations from MTAG-GBMI, MTAG-BBJ, Asthma-GBMI, Asthma-BBJ, and eosinophils. Newly identified loci are highlighted in red, and previously known loci are shown in black. MTAG-GBMI: Multi-trait analysis of GWAS applied to asthma data from the Global Biobank Meta-analysis Initiative (GBMI). This combines asthma and eosinophil GWAS data to identify shared loci. MTAG-BBJ: MTAG analysis using asthma data from BioBank Japan (BBJ) alongside eosinophil GWAS data. Asthma-GBMI: Single-trait GWAS results for asthma from GBMI. Asthma-BBJ: Single-trait GWAS results for asthma from BBJ. Eosinophils: Single-trait GWAS results for eosinophil counts. Source data are provided as a Source Data file.
