Fig. 6: Proposed model of DELLAs-DOF6-GA20ox3 module in A. thaliana.

The transcript of the gibberellin biosynthetic gene GA20ox3 is negatively feedback-regulated by DELLA proteins in a DOF6-dependent manner. The DOF6-GA20ox3-mediated GA signaling pathway is influenced by cold. SNPs in the GA20ox3 promoter region affect the recognition efficiency of DOF6, causing differences in fruit length and seed germination timing. Hap1/4 and Hap2/3 have developed distinct adaptive mechanisms to cope with variations in cold exposure duration resulting from differences in high and low altitudes.