Table 2 Deletions in NYC MPXV genome sequences
From: Genomic epidemiology of mpox virus during the 2022 outbreak in New York City
Deletion | Gene(s) | Protein (Function) | # of sequence(s) with deletion |
|---|---|---|---|
8197:9315 | OPG021 | Host range factor p28 (Plays an important role in virulence by acting as an anti-apoptotic factor) | 2 |
13543:16819 | OPG025-OPG027 | Ankyrin repeat protein (Plays a role in the inhibition of host immune response); Interferon antagonist OPG027 (Inhibits antiviral activity induced by type I interferons) | 1 |
11326:12237/8 | OPG023 | Ankyrin repeat domain-containing protein (Prevents activation and subsequent nuclear localization of NF-kappa-B in infected cells) | 6 |
149273:149608 | OPG174-175 | 3 beta-hydroxysteroid dehydrogenase (Contributes to virulence by inhibiting the host inflammatory response); Cu-Zn superoxide dismutase-like protein | 1 |
159745:160509 | OPG185 | Protein OPG185/Hemagglutinin (Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane) | 1 |
