Fig. 2: Categorization of switch-like genes.
A PCA analysis of tissue-pair correlations of gene expression. Each point represents a gene. When we perform PCA on the tissue-to-tissue co-expression vectors for 19,121 genes, the switch-like genes divide into two clusters. Cluster 1 primarily represents genes that are bimodally expressed in a tissue-specific manner, while cluster 2 represents genes that are bimodally expressed in at least all non-sex-specific tissues. B Performing PCA on the co-expression vectors of only switch-like genes further divides cluster 2 into two subclusters: cluster 2 A, which contains genes that are bimodally expressed across all 27 tissues, and cluster 2B, which contains genes that are bimodally expressed in all 22 tissues common to both sexes, but not in the five sex-specific tissues. C–E Violin plots display the expression levels in all 27 tissues for representative genes from cluster 1, cluster 2A, and cluster 2B, respectively. log(TPM + 1)C refers to the value of log(TPM + 1) corrected for the effects of technical confounders. All panels were assembled as Fig. 2 in BioRender. Aqil, A. (2025) https://BioRender.com/bird6wi. Source data are provided as a Source Data file.
