Fig. 4: Integrated analysis of multiple single-cell sequencing datasets reveals conserved expression of the TProlif_Tox gene signature across HNSCCs without expression in normal tissues. | Nature Communications

Fig. 4: Integrated analysis of multiple single-cell sequencing datasets reveals conserved expression of the TProlif_Tox gene signature across HNSCCs without expression in normal tissues.

From: Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer

Fig. 4

a Integrated analyses of multiple internal and external datasets with T cells subsetted demonstrates (b) conserved clustering and T cell functional groups. c Despite globally conserved transcriptional T cell sub-classifications, the TProlif_Tox gene signature is tumor-specific without any expression in normal oral mucosa. Pre-ex Pre-exhausted T cells, Reg Regulatory T cells, Prolif Proliferative T cells, Ex Exhausted T cells.

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