Fig. 3: Spatial profiling of chromatin accessibility in FFPE human cerebellum.
From: Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues
a Spatial-FFPE-ATAC-seq profiling of a FFPE human cerebellum section (n = 1). Left: tissue scanning after microfluidic device barcoding. Middle: spatial distribution of unique fragments. Right: spatial pattern and UMAP of each cluster. b H&E-stained image of an adjacent tissue section (n = 1). Arrows labeled the molecular layer, cerebellar medulla, and granular layer regions. c Integration of scRNA-seq data19 with spatial-FFPE-ATAC-seq from human cerebellum. d–f Spatial mapping of selected cell types identified through label transfer: oligodendrocytes (d) and granule cells (e). f, g Genome track visualization of selected marker genes across different clusters. Scale bar: 500 μm.
