Fig. 8: Inhibition of SM1PAG and SM1RVM neurons blocked motor-induced analgesia. | Nature Communications

Fig. 8: Inhibition of SM1PAG and SM1RVM neurons blocked motor-induced analgesia.

From: Descending projection neurons in the primary sensorimotor cortex regulate neuropathic pain and locomotion in mice

Fig. 8

a Schematic showing the experiment design for motor induced analgesia. b and c Effects of locomotion on von Frey threshold (left) and Hargreaves latency (right) in CCI (b von Frey, P = 0.0130, Hargreaves, P = 0.0162) or naïve (c von Frey, P = 0.8834, Hargreaves, P = 0.4848) mice. d Schematic showing the viral strategy for optogenetic blocking SM1PAG neurons. e Optogenetic inhibition of SM1PAG neurons blocked motor induced analgesia (P = 0.0196). f Schematic showing the viral strategy for optogenetic blocking SM1RVM neurons. g Optogenetic inhibition of SM1RVM neurons blocked motor induced analgesia (P = 0.0011). All data are expressed as mean ± sem, and (b and c) were analyzed by two-tailed unpaired t test or Mann Whitney test, (e and g) were analyzed by Brown-Forsythe ANOVA test followed by Dunnett’s multiple comparisons test. Sample sizes are indicated in the figures, with detailed statistics provided in Supplementary Data 1. *P ≤ 0.05, **P ≤ 0.01. Source data are provided as a Source Data file.

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