Fig. 1: Cryo-EM structures of native PMEL amyloids. | Nature Communications

Fig. 1: Cryo-EM structures of native PMEL amyloids.

From: Cryo-EM of wild-type and mutant PMEL amyloid cores reveals structural mechanism of pigment dispersion syndrome

Fig. 1

a Cryo-EM images of native PMEL amyloids extracted from the human melanoma cell line, showing both thick (two-protofilament) and thin (single-protofilament) fibrils (Fig. S1, squares). For each condition, the imaging experiment was independently repeated three times using separately prepared grids, yielding consistent results. b Side views of the reconstructed 3D maps of the two-protofilament fibrils, illustrating the overall helical structure of the amyloids.

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