Fig. 3: Structure of the pol ι binary product complexes.
From: Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis
(A) Close-up of the active site of the pol ι binary product complex formed in crystallo with the newly formed base pair labeled n, the primer-terminal base pair labeled n-1, and the base on the 5′ side of the template base labeled n + 1. (B) Close-up of the active site of the co-crystallized pre-translocation pol ι binary product complex with the newly formed base pair labeled n in the nascent base pair binding pocket and the primer-terminal base pair labeled n-1 in the primer-terminal base pair binding pocket. (C) Close-up of the active site of the co-crystallized post-translocation pol ι binary product complex with the newly formed base pair labeled n in the primer-terminal base pair binding pocket, and the new template base labeled n + 1 is in the nascent base pair binding pocket.
