Fig. 2: CD37 is widely expressed in macrophages.

A The proportion of CD37⁺ macrophages derived from different cancer species measured by FACS, BRCA breast cancer, GBM glioblastoma, CRC colon-rectum cancer, LC lung cancer, PDAC pancreatic ductal adenocarcinoma, n = 38 for each cancer, data were presented as individual dots. B The proportion of CD37⁺ macrophages derived from different single-cell sequence of different cancer species, BRCA breast cancer, GBM glioblastoma, CRC colon-rectum cancer, LC lung cancer, PDAC pancreatic ductal adenocarcinoma, n = 5 for each cancer, data were presented as box plot, the mean value, maximum and minimum values, and the quartile values were presented. C The violin plot of CD37 and three other checkpoints (PDCD1, SIRPA, and SLAMF7) in macrophages from different cancer species, BRCA breast cancer, GBM glioblastoma, CRC colon-rectum cancer, LC lung cancer, PDAC pancreatic ductal adenocarcinoma, n = 5 for each cancer, each white dot within the violin plot represents the median. The thick black bar in the center indicates the interquartile range, with the upper end marking the third quartile and the lower end marking the first quartile. The thin black line extending from the bar represents the data range, with the upper end indicating the maximum value and the lower end the minimum value. The width of the violin reflects the relative density of the data, with wider regions indicating a higher probability of observed values. D The single-cell sequence of breast cancer (GSE150660) was analyzed, the UMAP of macrophages was obtained, and the expression distribution of CD37, MRC1, and CD86 was demonstrated. All the experiments were repeated at least three times with similar results.